Four steps: the original, what makes it special, the parts we use, and how to get closer.
SkinBetter Science
~$200 Price not confirmed · 1.7 fl oz (50 ml); also 1 fl oz (30 ml)
A peptide-rich cream that uses 'InterFuse' delivery to carry collagen-supporting 'messenger' peptides and a Syn-Ake-type neuro-calming peptide into the skin, along with olive fruit extract for antiox…
Prices and listings checked Oct 28, 2026. Amazon prices change; the link shows today's price.
These peptides are what the brand points to for firmer, smoother-looking skin.
No close retail equivalent: we credit at most 50% of these points.
Aimed at softening expression lines, the second half of the firmness claim.
A plant antioxidant that supports comfort and redness.
The emollient base is what makes this a cream for the neck, not a serum.
Keeps the skin supple under the peptides.
Multi-peptide serum + Olay cream
IllustrationPart 1 · The Ordinary
Multi-peptide serum
IllustrationPart 2 · Olay
Peptide moisturizer
IllustrationPart 3 · The Ordinary
Hyaluronic acid hydration
How to use. Patch test any new active on the inner forearm or behind the ear for 24-48 hours first. PM: peptide serum, then Olay cream on face and neck. AM: Olay cream plus SPF 30+. Do not combine copper peptides with a strong vitamin C in the same step. Add The Ordinary Hyaluronic Acid 2% + B5 (with Ceramides): covers Glycerin and hydration support.
Partial credit means the part only partly matches that standout.
62 / 100. We have not found a shelf product that closes more of the gap yet.
83 is our ceiling. The exact InterFuse peptide pair and delivery system are not sold at retail; Matrixyl-family or tripeptide-5 products give partial credit.
One bottle instead of a build. Sorted by match score; scores use the same standouts as above.
The Ordinary
No close match yet — we show the nearest formulas.
Why it is close. Widest peptide overlap: it lists the same dipeptide diaminobutyroyl benzylamide diacetate as InterFuse plus the palmitoyl peptides. It is a serum, so layer a plain moisturizer on top. At $32 it is the most expensive dupe here but still about one-sixth of the original.
Olay
Why it is close. Closest vehicle match (a cream for face and neck with peptides) at drugstore price. Specific peptides differ and full INCI was not retrieved.
The Ordinary
Why it is close. Delivers signalling peptides of the same palmitoyl-peptide family that InterFuse uses for collagen support. It is a light serum so you need a moisturizer over it.
The Ordinary
Why it is close. Argireline is a published neuro-calming peptide, similar in goal to InterFuse's neuro-calming peptides for expression lines. Pair with Matrixyl for the signalling half.
Palmitoyl pentapeptide (Matrixyl) 3 ppm reduced wrinkles/fine lines vs placebo in a 12-week split-face trial.
Robinson 2005 · Int J Cosmet SciAcetyl hexapeptide-8 (Argireline) 10% emulsion reduced wrinkle depth by up to 30% over 30 days and inhibits neurotransmitter release in vitro.
Blanes-Mira 2002 · Int J Cosmet SciTopical niacinamide improves wrinkles and elasticity in aging facial skin.
Bissett 2005 · Dermatol SurgAqua/Water, Glycerin, Isododecane, Dimethicone, C12-15 Alkyl Benzoate, Cyclopentasiloxane, PEG-16 Macadamia Glycerides, Butyrospermum Parkii (Shea) Butter, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Palmitoyl Tripeptide-5, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Olea Europaea (Olive) Fruit Extract, Cetearyl Dimethicone Crosspolymer, Cetyl Alcohol, Polyisobutene, Caprylyl/Capryl Glucoside, Glyceryl Stearate, Alcohol Denat., Ammonium Acryloyldimethyltaurate/VP Copolymer, Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Sorbitan Oleate, Ceteth-20, Steareth-20, PEG-75 Stearate, Disodium EDTA, Magnesium Chloride, Citric Acid, Sodium Hydroxide, Ethylhexylglycerin, Hexylene Glycol, Caprylyl Glycol, Phenoxyethanol, Mica, Titanium Dioxide (CI 77891)
We split InterFuse Treatment Cream FACE & NECK into 5 standout parts worth 100 points in total. The build earns 62 of a possible 83. 83 is the most we claim, because some standouts have no close retail equivalent.
The Ordinary "Buffet" + Copper Peptides 1% (now sold as Multi-Peptide + Copper Peptides 1%) by The Ordinary is our closest single-product match at 37 out of 100 for $32 (1 fl oz (30 ml)). It shares Palmitoyl tripeptide-1, Palmitoyl tetrapeptide-7, Acetyl hexapeptide-8, Copper tripeptide-1, Dipeptide diaminobutyroyl benzylamide diacetate (the same Syn-Ake type peptide InterFuse lists).
InterFuse Treatment Cream FACE & NECK costs ~$200 for 1.7 fl oz (50 ml); also 1 fl oz (30 ml). The closest dupe costs $32, a saving of about $168. Prices change, so check the seller page.
No. Dupes share the key actives but can differ in concentration, vehicle and supporting ingredients. Missing from this one: Olive extract, Cream base. See our methodology for how we score.
