The original, what makes it special, the shelf parts we use and how to get closer. Add or swap parts and the score updates.
The original · SkinMedica
$72 · 2 oz (57 g)
A barrier-support cream with the TNS growth factor blend, a ceramide-like lipid (hydroxypropyl bispalmitamide MEA), peptides, tetrahexyldecyl ascorbate, retinyl palmitate and hyaluronate in an emolli…
Prices and listings checked Oct 28, 2026. Amazon prices change; the link shows today's price.
Step 2 · The build
CeraVe
Partial credit means the part only partly matches that standout.
The 100 points
We split TNS Ceramide Treatment Cream into 4 standout parts. Each bar shows what the build earns.
Hydroxypropyl bispalmitamide MEA is a ceramide analog that helps rebuild barrier lipids.
The brand's signature ingredient; not at retail.
No close retail equivalent: we credit at most 25% of these points.
Signal peptides with an oil-soluble vitamin C.
Plant lipids and squalane soften and seal.
Optional
56 / 100. We have not found a shelf product that closes more of the gap yet.
81 is our ceiling. TNS growth factor blend has no close retail equivalent, so we cap it at 25% credit.
Step 3 · Buy
One link per part. Each opens the retailer in a new tab.
Your build
Running total $15.49
Buy on Amazon (opens in new tab)Snapshot prices. Each link shows today's price.
One bottle instead of a build. Sorted by match score; scores use the same standouts as above.
CeraVe
No close match yet — we show the nearest formulas.
Why it is close. A night cream built on three ceramides, hyaluronate and a peptide complex at a fraction of the price.
Naturium
Why it is close. A multi-peptide cream, similar in feel, without the ceramide analog.
Olay
Why it is close. A peptide moisturizer that covers the lines angle but not the barrier lipid or growth factors.
CeraVe
Running total
Buy on Amazon (opens in new tab)No gain nowCeraVe
Olay
Running total
Buy on Amazon (opens in new tab)No gain nowOlay
Naturium
Running total
Buy on Amazon (opens in new tab)No gain nowNaturium
Ceramide-containing moisturizers raised stratum corneum lipid levels in a trial.
Draelos 2020 · J Drugs DermatolOver-the-counter moisturizers significantly improved skin hydration.
Nguyen 2023 · J Drugs DermatolWater/Aqua/Eau, Cetyl Ethylhexanoate, Cetearyl Alcohol, Hydroxypropyl Bispalmitamide MEA, Human Fibroblast Conditioned Media, Dimethicone, Olea Europaea Fruit Oil, Glycine Soja Oil, Glycerin, Cetearyl Glucoside, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Tetrahexyldecyl Ascorbate, Avena Sativa Kernel Extract, Glycine Soja Sterols, Retinyl Palmitate, Tocopheryl Acetate, Sodium Carboxymethyl Beta-Glucan, Squalane, Allantoin, Bisabolol, Panthenol, Sodium Hyaluronate, Xanthan Gum, Glyceryl Stearate, PEG-100 Stearate, Isoceteth-20, Butylene Glycol, Ethoxydiglycol, Carbomer, Disodium EDTA, Ethylhexylglycerin, Phenoxyethanol, Caprylyl Glycol, Caprylhydroxamic Acid, Potassium Sorbate
Ingredient list from a third-party listing, not confirmed on the brand site. Source
We split TNS Ceramide Treatment Cream into 4 standout parts worth 100 points in total. The build earns 56 of a possible 81. 81 is the most we claim, because some standouts have no close retail equivalent.
CeraVe Skin Renewing Night Cream by CeraVe is our closest single-product match at 56 out of 100 for $15.49 (1.7 oz). It shares Ceramides, Peptide complex, Hyaluronic acid.
TNS Ceramide Treatment Cream costs $72 for 2 oz (57 g). The closest dupe costs $15.49, a saving of about $56.51. Prices change, so check the seller page.
No. Dupes share the key actives but can differ in concentration, vehicle and supporting ingredients. Missing from this one: Growth factor blend, Vitamin C. See our methodology for how we score.
SkinBetter Science · eye
~$65.90our build, 4 partsOriginal $130, build ~$65.90.
Neutrogena + The Ordinary
SkinBetter Science · moisturizer
~$76.84our build, 3 partsOriginal ~$200, build ~$76.84.
The Ordinary + Olay
SkinBetter Science · moisturizer
~$59.38our build, 4 partsOriginal ~$160, build ~$59.38.
CeraVe + The Ordinary + Vanicream