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How we build InterFuse Treatment Cream FACE & NECK

The original, what makes it special, the shelf parts we use and how to get closer. Add or swap parts and the score updates.

InterFuse Treatment Cream FACE & NECK

The original · SkinBetter Science

InterFuse Treatment Cream FACE & NECK

~$200 Price not confirmed · 1.7 fl oz (50 ml); also 1 fl oz (30 ml)

A peptide-rich cream that uses 'InterFuse' delivery to carry collagen-supporting 'messenger' peptides and a Syn-Ake-type neuro-calming peptide into the skin, along with olive fruit extract for antiox…

Official product page (opens in new tab)

Prices and listings checked Oct 28, 2026. Amazon prices change; the link shows today's price.

Step 2 · The build

Our build 3 parts

Multi-peptide serum + Olay cream

  • Illustration of The Ordinary "Buffet" + Copper Peptides 1% (now sold as Multi-Peptide + Copper Peptides 1%)

    The Ordinary

    The Ordinary "Buffet" + Copper Peptides 1% (now sold as Multi-Peptide + Copper Peptides 1%)

    Multi-peptide serum

    ACollagen-signalling messenger peptides (palmitoyl tripeptide-5, palmitoyl dipeptide-5) · 18 of 35BNeuro-calming peptides (Syn-Ake type dipeptide, tetradecyl aminobutyroylvalylaminobutyric urea) · 19 of 25
    $32Buy on Amazon (opens in new tab)
  • Illustration of Olay Regenerist Collagen Peptide 24 MAX Moisturizer (fragrance-free)

    Olay

    Olay Regenerist Collagen Peptide 24 MAX Moisturizer (fragrance-free)

    Peptide moisturizer

    ACollagen-signalling messenger peptides (palmitoyl tripeptide-5, palmitoyl dipeptide-5) · 14 of 35DShea, silicone and alkyl benzoate cream base · 15 of 20
    ~$34.94Buy on Amazon (opens in new tab)
  • Illustration of The Ordinary Hyaluronic Acid 2% + B5 (with Ceramides)

    The Ordinary

    The Ordinary Hyaluronic Acid 2% + B5 (with Ceramides)

    Hyaluronic acid hydration

    EGlycerin and hydration support · 10
    $9.90Buy on Amazon (opens in new tab)

Partial credit means the part only partly matches that standout.

The 100 points

What stands out 100 pts

We split InterFuse Treatment Cream FACE & NECK into 5 standout parts. Each bar shows what the build earns.

  • ACollagen-signalling messenger peptides (palmitoyl tripeptide-5, palmitoyl dipeptide-5)18 of 35 pts

    These peptides are what the brand points to for firmer, smoother-looking skin.

    No close retail equivalent: we credit at most 50% of these points.

    Robinson 2005 · Int J Cosmet Sci
  • BNeuro-calming peptides (Syn-Ake type dipeptide, tetradecyl aminobutyroylvalylaminobutyric urea)19 of 25 pts

    Aimed at softening expression lines, the second half of the firmness claim.

    Blanes-Mira 2002 · Int J Cosmet Sci
  • COlive fruit extract0 of 10 pts

    A plant antioxidant that supports comfort and redness.

  • DShea, silicone and alkyl benzoate cream base15 of 20 pts

    The emollient base is what makes this a cream for the neck, not a serum.

  • EGlycerin and hydration support10 of 10 pts

    Keeps the skin supple under the peptides.

Optional

Get closer score under 80

62 / 100. We have not found a shelf product that closes more of the gap yet.

83 is our ceiling. The exact InterFuse peptide pair and delivery system are not sold at retail; Matrixyl-family or tripeptide-5 products give partial credit.

Step 3 · Buy

Buy the build

One link per part. Each opens the retailer in a new tab.

Skincare SuppliesOct 28, 2026

Your build

  1. 01The OrdinaryThe Ordinary "Buffet" + Copper Peptides 1% (now sold as Multi-Peptide + Copper Peptides 1%)$32

    Running total $32

    Buy on Amazon (opens in new tab)
  2. 02OlayOlay Regenerist Collagen Peptide 24 MAX Moisturizer (fragrance-free)~$34.94

    Running total ~$66.94

    Buy on Amazon (opens in new tab)
  3. 03The OrdinaryThe Ordinary Hyaluronic Acid 2% + B5 (with Ceramides)$9.90

    Running total ~$76.84

    Buy on Amazon (opens in new tab)
Build total~$76.84
The splurge~$200
Match62/100
You keep~$123.16

Snapshot prices. Each link shows today's price.

How to use

  1. Patch test any new active on the inner forearm or behind the ear for 24-48 hours first. PM: peptide serum, then Olay cream on face and neck. AM: Olay cream plus SPF 30+. Do not combine copper peptides with a strong vitamin C in the same step.
  2. Add The Ordinary Hyaluronic Acid 2% + B5 (with Ceramides): covers Glycerin and hydration support.

Other single-product swaps

One bottle instead of a build. Sorted by match score; scores use the same standouts as above.

budget Closest we found

Naturium Multi-Peptide Moisturizer

Naturium

Match score 38 out of 100

No close match yet — we show the nearest formulas.

$19.99 · 50 ml / 1.7 fl oz
What it shares, what it misses

Shares

  • Niacinamide
  • Palmitoyl Tripeptide-5
  • Palmitoyl Tripeptide-1 / Palmitoyl Tetrapeptide-7
  • 3-O-Ethyl Ascorbic Acid
  • Squalane
  • Jojoba oil
  • Sodium Hyaluronate

Misses

  • Heptapeptide-7 / Hexapeptide-40 SH-Polypeptide-76
  • Adenosine / carnosine / magnesium gluconate / arginine
  • Aminopropyl Ascorbyl Phosphate (has ethyl ascorbic acid instead)
  • EGCG

Why it is close. Niacinamide is 8th on the list, with three signal peptides and ethyl ascorbic acid, in a squalane and jojoba cream; no concentrations are published.

Ingredient list source

Buy on Amazon (opens in new tab)
budget

The Ordinary "Buffet" + Copper Peptides 1% (now sold as Multi-Peptide + Copper Peptides 1%)

The Ordinary

Match score 37 out of 100
$32 · 1 fl oz (30 ml)
What it shares, what it misses

Shares

  • Palmitoyl tripeptide-1
  • Palmitoyl tetrapeptide-7
  • Acetyl hexapeptide-8
  • Copper tripeptide-1
  • Dipeptide diaminobutyroyl benzylamide diacetate (the same Syn-Ake type peptide InterFuse lists)

Misses

  • Olive extract
  • Cream base

Why it is close. Widest peptide overlap: it lists the same dipeptide diaminobutyroyl benzylamide diacetate as InterFuse plus the palmitoyl peptides. It is a serum, so layer a plain moisturizer on top. At $32 it is the most expensive dupe here but still about one-sixth of the original.

Ingredient list source

Buy on Amazon (opens in new tab)
budget

Olay Regenerist Collagen Peptide 24 MAX Moisturizer (fragrance-free)

Olay

Match score 29 out of 100
~$34.94 Price not confirmed · 1.7 oz
What it shares, what it misses

Shares

  • Peptides (palmitoyl pentapeptide-4 and others)
  • Cream moisturizer base
  • Niacinamide

Misses

  • Syn-Ake type peptide
  • Olive extract
  • Silicone-rich InterFuse delivery base

Why it is close. Closest vehicle match (a cream for face and neck with peptides) at drugstore price. Specific peptides differ and full INCI was not retrieved.

Ingredient list source

Buy on Amazon (opens in new tab)
budget

The Ordinary Matrixyl 10% + HA

The Ordinary

Match score 23 out of 100
$10.90 · 1 fl oz (30 ml)
What it shares, what it misses

Shares

  • Palmitoyl tripeptide-1 + palmitoyl tetrapeptide-7 (Matrixyl-family signalling peptides)
  • Sodium hyaluronate

Misses

  • Syn-Ake type peptide
  • Olive extract
  • Emollient cream base

Why it is close. Delivers signalling peptides of the same palmitoyl-peptide family that InterFuse uses for collagen support. It is a light serum so you need a moisturizer over it.

Ingredient list source

Buy on Amazon (opens in new tab)
budget

The Ordinary Argireline Solution 10%

The Ordinary

Match score 13 out of 100
$9.70 · 1 fl oz (30 ml)
What it shares, what it misses

Shares

  • Acetyl hexapeptide-8 (Argireline, 10%)

Misses

  • Collagen-signalling peptides
  • Olive extract
  • Emollient base

Why it is close. Argireline is a published neuro-calming peptide, similar in goal to InterFuse's neuro-calming peptides for expression lines. Pair with Matrixyl for the signalling half.

Ingredient list source

Buy on Amazon (opens in new tab)

What the science says

Full ingredient list

Show the INCI list

Aqua/Water, Glycerin, Isododecane, Dimethicone, C12-15 Alkyl Benzoate, Cyclopentasiloxane, PEG-16 Macadamia Glycerides, Butyrospermum Parkii (Shea) Butter, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Palmitoyl Tripeptide-5, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Olea Europaea (Olive) Fruit Extract, Cetearyl Dimethicone Crosspolymer, Cetyl Alcohol, Polyisobutene, Caprylyl/Capryl Glucoside, Glyceryl Stearate, Alcohol Denat., Ammonium Acryloyldimethyltaurate/VP Copolymer, Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Sorbitan Oleate, Ceteth-20, Steareth-20, PEG-75 Stearate, Disodium EDTA, Magnesium Chloride, Citric Acid, Sodium Hydroxide, Ethylhexylglycerin, Hexylene Glycol, Caprylyl Glycol, Phenoxyethanol, Mica, Titanium Dioxide (CI 77891)

Source

Questions

What does the 62/100 score for our InterFuse Treatment Cream FACE & NECK build mean?

We split InterFuse Treatment Cream FACE & NECK into 5 standout parts worth 100 points in total. The build earns 62 of a possible 83. 83 is the most we claim, because some standouts have no close retail equivalent.

What is the best dupe for InterFuse Treatment Cream FACE & NECK?

Naturium Multi-Peptide Moisturizer by Naturium is our closest single-product match at 38 out of 100 for $19.99 (50 ml / 1.7 fl oz). It shares Niacinamide, Palmitoyl Tripeptide-5, Palmitoyl Tripeptide-1 / Palmitoyl Tetrapeptide-7, 3-O-Ethyl Ascorbic Acid, Squalane, Jojoba oil, Sodium Hyaluronate.

How much can I save on InterFuse Treatment Cream FACE & NECK?

InterFuse Treatment Cream FACE & NECK costs ~$200 for 1.7 fl oz (50 ml); also 1 fl oz (30 ml). The closest dupe costs $19.99, a saving of about $180.01. Prices change, so check the seller page.

Is Naturium Multi-Peptide Moisturizer exactly the same as InterFuse Treatment Cream FACE & NECK?

No. Dupes share the key actives but can differ in concentration, vehicle and supporting ingredients. Missing from this one: Heptapeptide-7 / Hexapeptide-40 SH-Polypeptide-76, Adenosine / carnosine / magnesium gluconate / arginine, Aminopropyl Ascorbyl Phosphate (has ethyl ascorbic acid instead), EGCG. See our methodology for how we score.

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