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How we build InterFuse Intensive Treatment LINES

The original, what makes it special, the shelf parts we use and how to get closer. Add or swap parts and the score updates.

InterFuse Intensive Treatment LINES

The original · SkinBetter Science

InterFuse Intensive Treatment LINES

~$245 Price not confirmed · 1 fl oz (30 ml); also 0.5 fl oz (15 ml)

A concentrated, no-needle 'filler-style' serum that delivers several sizes of hyaluronic acid (including injectable-grade HA and a sodium acetylated HA) in a silicone/ester vehicle, alongside a vitam…

Official product page (opens in new tab)

Prices and listings checked Oct 28, 2026. Amazon prices change; the link shows today's price.

Step 2 · The build

Our build 4 parts

Argireline + Matrixyl + HA

  • Illustration of The Ordinary Argireline Solution 10%

    The Ordinary

    The Ordinary Argireline Solution 10%

    Neuro-calming peptide

    AAcetyl hexapeptide-8 + related expression-line peptides · 19 of 25
    $9.70Buy on Amazon (opens in new tab)
  • Illustration of The Ordinary Matrixyl 10% + HA

    The Ordinary

    The Ordinary Matrixyl 10% + HA

    Collagen-signalling peptides + HA

    BPalmitoyl tripeptide-1 and tetrapeptide-7 · 20CMulti-weight hyaluronic acid · 13 of 25
    $10.90Buy on Amazon (opens in new tab)
  • Illustration of The Ordinary Hyaluronic Acid 2% + B5 (with Ceramides)

    The Ordinary

    The Ordinary Hyaluronic Acid 2% + B5 (with Ceramides)

    Multi-weight hyaluronic acid

    CMulti-weight hyaluronic acid · 19 of 25
    $9.90Buy on Amazon (opens in new tab)
  • Illustration of Paula's Choice CLINICAL 1% Retinol Treatment

    Paula's Choice

    Paula's Choice CLINICAL 1% Retinol Treatment

    Adds: Tetrahexyldecyl ascorbate

    BPalmitoyl tripeptide-1 and tetrapeptide-7 · 10 of 20DTetrahexyldecyl ascorbate · 11 of 15
    $65Buy on Amazon (opens in new tab)

Partial credit means the part only partly matches that standout.

The 100 points

What stands out 100 pts

We split InterFuse Intensive Treatment LINES into 5 standout parts. Each bar shows what the build earns.

  • AAcetyl hexapeptide-8 + related expression-line peptides19 of 25 pts

    Peptides aimed at softening expression lines like the forehead and crow's feet.

    Blanes-Mira 2002 · Int J Cosmet Sci
  • BPalmitoyl tripeptide-1 and tetrapeptide-720 of 20 pts

    Matrikine peptides that signal skin to look firmer.

    Robinson 2005 · Int J Cosmet Sci
  • CMulti-weight hyaluronic acid19 of 25 pts

    Several HA sizes hydrate and plump the surface, the part you feel right away.

    Pavicic 2011 · J Drugs Dermatol
  • DTetrahexyldecyl ascorbate11 of 15 pts

    An oil-soluble vitamin C that supports tone and firmness.

    Lintner 2020 · J Cosmet Dermatol
  • EInterFuse delivery vehicle and injectable-grade HA0 of 15 pts

    The silicone/ester vehicle and injectable-grade HA are what this brand says gets the HA to work like a no-needle filler.

    No close retail equivalent: we credit at most 30% of these points.

Optional

Get closer score under 80

69 / 100. We have not found a shelf product that closes more of the gap yet.

90 is our ceiling. The delivery system and injectable-grade HA are proprietary; cheaper serums can match the ingredient list but not the vehicle.

Step 3 · Buy

Buy the build

One link per part. Each opens the retailer in a new tab.

Skincare SuppliesOct 28, 2026

Your build

  1. 01The OrdinaryThe Ordinary Argireline Solution 10%$9.70

    Running total $9.70

    Buy on Amazon (opens in new tab)
  2. 02The OrdinaryThe Ordinary Matrixyl 10% + HA$10.90

    Running total $20.60

    Buy on Amazon (opens in new tab)
  3. 03The OrdinaryThe Ordinary Hyaluronic Acid 2% + B5 (with Ceramides)$9.90

    Running total $30.50

    Buy on Amazon (opens in new tab)
  4. 04Paula's ChoicePaula's Choice CLINICAL 1% Retinol Treatment$65

    Running total $95.50

    Buy on Amazon (opens in new tab)
Build total$95.50
The splurge~$245
Match69/100
You keep~$149.50

Snapshot prices. Each link shows today's price.

How to use

  1. Patch test any new active on the inner forearm or behind the ear for 24-48 hours first. AM/PM on lines (forehead, between brows, crow's feet, smile lines): HA serum on damp skin, then Argireline, then Matrixyl, then moisturizer. Add vitamin C (Timeless) in the AM if you want the vitamin C piece. SPF 30+ daily. Results take 8-12 weeks.
  2. Add Paula's Choice CLINICAL 1% Retinol Treatment: Contains THD ascorbate, the same vitamin C ester, plus peptides.

Other single-product swaps

One bottle instead of a build. Sorted by match score; scores use the same standouts as above.

budget Closest we found

The Ordinary "Buffet" + Copper Peptides 1% (now sold as Multi-Peptide + Copper Peptides 1%)

The Ordinary

Match score 47 out of 100

No close match yet — we show the nearest formulas.

$32 · 1 fl oz (30 ml)
What it shares, what it misses

Shares

  • Acetyl hexapeptide-8
  • Palmitoyl tripeptide-1
  • Palmitoyl tetrapeptide-7
  • Dipeptide diaminobutyroyl benzylamide diacetate
  • Sodium hyaluronate crosspolymer + sodium hyaluronate

Misses

  • Vitamin C ester (THD ascorbate)
  • Injectable-grade HA delivery vehicle

Why it is close. This is the closest ingredient match: it contains four of LINES's five named peptides and two HA forms. It costs about $32 for 30 ml versus $245. The silicone-ester delivery vehicle is the main thing you lose.

Ingredient list source

Buy on Amazon (opens in new tab)
budget

The Ordinary Matrixyl 10% + HA

The Ordinary

Match score 33 out of 100
$10.90 · 1 fl oz (30 ml)
What it shares, what it misses

Shares

  • Palmitoyl tripeptide-1
  • Palmitoyl tetrapeptide-7
  • Sodium hyaluronate

Misses

  • Acetyl hexapeptide-8
  • Vitamin C ester
  • Additional HA weights

Why it is close. Two of LINES's peptides plus HA in one bottle at about $11.

Ingredient list source

Buy on Amazon (opens in new tab)
budget

The Ordinary Argireline Solution 10%

The Ordinary

Match score 19 out of 100
$9.70 · 1 fl oz (30 ml)
What it shares, what it misses

Shares

  • Acetyl hexapeptide-8 (Argireline, 10%)

Misses

  • Other peptides
  • Hyaluronic acid
  • Vitamin C ester

Why it is close. Argireline is a core active of LINES and is published at 10% here, which matches the expression-line goal. Pair with an HA serum.

Ingredient list source

Buy on Amazon (opens in new tab)
budget

The Ordinary Hyaluronic Acid 2% + B5 (with Ceramides)

The Ordinary

Match score 19 out of 100
$9.90 · 1 fl oz (30 ml)
What it shares, what it misses

Shares

  • Sodium hyaluronate (multiple molecular weights, including crosspolymer)
  • Panthenol

Misses

  • All peptides
  • Vitamin C ester

Why it is close. Covers the multi-weight hyaluronic acid hydration half, the part users feel immediately as plumping.

Ingredient list source

Buy on Amazon (opens in new tab)

What the science says

Full ingredient list

Show the INCI list

Water (Aqua), C12-15 Alkyl Benzoate, Glycerin, PEG-16 Macadamia Glycerides, Dimethicone, Acetyl Glucosamine, Alcohol Denat, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Sodium Citrate, Tetrahexyldecyl Ascorbate, Sodium Hyaluronate, Polyisobutene, Phenoxyethanol, Glycine Soja (Soybean) Seed Extract, Oleic Acid, Glucosamine Hcl, Ophiopogon Japonicus Root Extract, Pisum Sativum (Pea) Extract, Sorbitan Laurate, Citric Acid, Caprylyl Glycol, Bambusa Vulgaris Leaf/Stem Extract, PEG-7, Trimethylolpropane, Coconut, Sorbitan Isostearate, Hexylene Glycol, Acetylated Glycol Stearate, C18-36 Acid Glycol Ester, C18-36 Acid Triglyceride, Ethylhexylglycerin, Sodium Acetylated Hyaluronate, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Hydrolyzed Lupine Protein, Glycine, Potassium Sorbate, Hydroxyproline, Carbomer, Hexapeptide-48 Hcl, Proline, Acetyl Hexapeptide-8, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7

Source

Questions

What does the 69/100 score for our InterFuse Intensive Treatment LINES build mean?

We split InterFuse Intensive Treatment LINES into 5 standout parts worth 100 points in total. The build earns 69 of a possible 90. 90 is the most we claim, because some standouts have no close retail equivalent.

What is the best dupe for InterFuse Intensive Treatment LINES?

The Ordinary "Buffet" + Copper Peptides 1% (now sold as Multi-Peptide + Copper Peptides 1%) by The Ordinary is our closest single-product match at 47 out of 100 for $32 (1 fl oz (30 ml)). It shares Acetyl hexapeptide-8, Palmitoyl tripeptide-1, Palmitoyl tetrapeptide-7, Dipeptide diaminobutyroyl benzylamide diacetate, Sodium hyaluronate crosspolymer + sodium hyaluronate.

How much can I save on InterFuse Intensive Treatment LINES?

InterFuse Intensive Treatment LINES costs ~$245 for 1 fl oz (30 ml); also 0.5 fl oz (15 ml). The closest dupe costs $32, a saving of about $213. Prices change, so check the seller page.

Is The Ordinary "Buffet" + Copper Peptides 1% (now sold as Multi-Peptide + Copper Peptides 1%) exactly the same as InterFuse Intensive Treatment LINES?

No. Dupes share the key actives but can differ in concentration, vehicle and supporting ingredients. Missing from this one: Vitamin C ester (THD ascorbate), Injectable-grade HA delivery vehicle. See our methodology for how we score.

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