SkinBetter Science / moisturizer
Prices and listings checked Oct 28, 2026. Amazon prices change; the link shows today's price.
A richer version of the Trio formula for moderate-to-severely dry skin, combining ceramides, cholesterol and fatty acids with NMFs and hyaluronate. Unlike Trio Rebalancing it adds niacinamide for barrier and tone support and drops the salicylic/lactic acids. The velvety texture supports barrier recovery and comfort.
| Active | Role | Amount |
|---|---|---|
| Niacinamide | barrier and tone support | not published |
| Ceramide EOP / NP | barrier lipid | not published |
| Cholesterol | barrier lipid | not published |
| Urea, sodium PCA, sodium lactate | natural moisturizing factors | not published |
| Hydrolyzed sodium hyaluronate | humectant | not published |
| Aminopropyl ascorbyl phosphate | vitamin C derivative | not published |
Grouped by price tier; priced products first, then closest match.
Target up&up
No close match yet — we show the nearest formulas.
Why it is close. Store-brand ceramide + niacinamide lotion; lacks Trio's urea/PCA/lactate NMF blend and acids.
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CeraVe
Why it is close. Adds peptides and niacinamide to the ceramide base, closest to Trio Luxe's anti-age angle.
Buy on Amazon (opens in new tab)Vanicream
Why it is close. Five ceramides, squalane and carnosine (also in Trio); very low irritant profile.
Buy on Amazon (opens in new tab)CeraVe
Why it is close. Rich ceramide cream with petrolatum for very dry skin; much heavier and no niacinamide.
Buy on Amazon (opens in new tab)Paula's Choice
Why it is close. Multi-ceramide plus peptide barrier cream at roughly a quarter of Trio Luxe's price. Price and ingredient list not re-checked.
Buy on Amazon (opens in new tab)How to use. PM: NMF + HA first, night cream over it.
Why it works. Gets niacinamide, ceramides, urea and PCA; lacks carnitine and the vitamin C derivative.
How to use. AM: up&up PM. PM: Moisturizing Cream.
Why it works. Splits niacinamide (AM) from the heavy occlusive cream (PM).
Niacinamide improved barrier function and aging-skin signs in clinical studies
Bissett 2005 · Dermatol SurgCeramide-containing moisturizer increased stratum corneum lipid levels
Draelos 2020 · J Drugs DermatolOTC moisturizers improved hydration in atopy-prone skin
Nguyen 2023 · J Drugs DermatolAqua/Water, Glycol Palmitate, Glyceryl Stearate, Cholesterol, Niacinamide, Caprylic/Capric/Myristic/Stearic Triglyceride, Jojoba Esters, Glycerin, Polyglyceryl-6 Palmitate/Succinate, Hydroxyethyl Urea, Sodium Lactate, Sodium PCA, Squalane, Cetearyl Alcohol, Glycine, Hydrolyzed Sodium Hyaluronate, Urea, Aminopropyl Ascorbyl Phosphate, Olea Europaea (Olive) Fruit Extract, Salicornia Herbacea Extract, Ceramide EOP, Ceramide NP, Linoleic Acid, Linolenic Acid, Carnosine, Caffeine, Tocopherol, Caprylic/Capric Triglyceride, Dimethicone, Pullulan, Sclerotium Gum, Xanthan Gum, Ethylhexylglycerin, Triethyl Citrate, Silica, Lecithin, Phytic Acid, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Triacetin, Sodium Hydroxide, Phenoxyethanol, Citric Acid
up&up PM Facial Moisturizing Lotion by Target up&up is our closest match at 60 out of 100 for $11.99 (3 fl oz). It shares niacinamide, ceramide NP/AP/EOP, sodium hyaluronate, cholesterol, glycerin.
Trio Luxe Moisture Treatment costs ~$180 for 1.7 fl oz / 50 ml. The closest dupe costs $11.99, a saving of about $168.01. Prices change, so check the seller page.
No. Dupes share the key actives but can differ in concentration, vehicle and supporting ingredients. Missing from this one: urea, sodium PCA, sodium lactate, carnitine, salicylic acid, lactic acid, aminopropyl ascorbyl phosphate. See our methodology for how we score.
moisturizer
SkinBetter Science / 1.7 fl oz / 50 ml
Best dupe: up&up PM Facial Moisturizing Lotion (60/100 match)
cleanser
SkinBetter Science / 8 fl oz / 237 ml
Best dupe: CeraVe Hydrating Facial Cleanser (68/100 match)
moisturizer
SkinBetter Science / 50 ml jar
Best dupe: up&up PM Facial Moisturizing Lotion (60/100 match)